Subclinical Characteristics and Treatment Results of Shigella in the Pediatric Department, Vietnam – Cuba Dong Hoi Friendship Hospital, 2019

Nguyen Hong Tu

Main Article Content

Abstract

Purpose: To describe some subclinical characteristics of Shigella dysentery in children at the Pediatric Department, Vietnam - Cuba Dong Hoi Friendship Hospital in 2019 and review the results of treatment in these patients.


Methods: A cross-sectional descriptive study was conducted on patients under 15 years old admitted to the Pediatric Department, Vietnam - Cuba Dong Hoi Friendship Hospital.


Results: The CRP index increased to 81.8%, of which the increase was mainly in the S.sonnei group. The rate of the most common bacteria strain is S.sonnei accounting for 87.1%, followed by S.fexneri 11.8%, S.dysenteriae encountered a case of 1.1%. No cases of stool culture resulted in S.boydii. The cure rate with Ciprofloxacin is 89.5%. The recovery rate is quite high, 93.3%, the percentage of patients who are also significantly better is 6.7% and there is no case of treatment failure.


Conclusions: The number of leukocytes and CRP in the peripheral blood increased in most cases. The main antibiotic used is Ciprofloxacin, the treatment effectiveness with Ciprofloxacin antibiotic is 89.5%, the cure rate is high and there is no case of treatment failure.

Article Details

Keywords

Shigella, subclinical, antibiotic

References

[1] WHO. Guidelines for the control of shigellosis, including epidemics due to Shigella dysenteriae 1. Geneva, World Health Organisation; 2005.
[2] WHO. Shigellosis: disease burden, epidemiology and case management. Wkly Epidemiol Rec 2005;80(11):94-99.
[3] Ministry of Health. Guidelines for managing diarrhea in children; 2009.
[4] Bodhidatta L, Lan NTP, Hien BT et al. Rotavirus disease in young children from Hanoi, Vietnam. Pediatr Infect Dis J 2007;26(4):325-328. https://doi.org/10.10 97/01.inf.0000257426.37289.8c.
[5] Hien BTT, Scheutz F, Cam PD et al. Diarrheagenic Escherichia coli and Shigella strains isolated from children in a hospital case-control study in Hanoi, Vietnam. J Clin Microbiol 2008;46(3):996-1004.
https://doi.org/10.1128/JCM.01219-07.
[6] Kelly-Hope LA, Alonso WJ, Thiem VD et al. Geographical distribution and risk factors associated with enteric diseases in Vietnam. Am J Trop Med Hyg 2007;76(4):706-712. https://doi.org/10.4269/ajtmh.200 7.76.706.
[7] Kosek M, Bern C, Guerrant RL. The global burden of diarrhoeal disease, as estimated from studies published between 1992 and 2000. Bull World Health Organ 2003;81(3):197-204.
[8] Nhu NTK, Vinh H, Nga TVT et al. The Sudden Dominance of blaCTX–M Harbouring Plasmids in Shigella spp. Circulating in Southern Viet Nam. PLoS Negl Trop Dis 2010;4(6):e702. https://doi.org/10.1371/journal.pntd.0000702
[9] Pitout JD. Infections with extended-spectrum betalactamase-producing enterobacteriaceae: changing epidemiology and drug treatment choices. Drugs 2010;70(3):313-333. https://doi.org/10.216/11533040000000000-00000
[10] Vinh H, Baker S, Campbell J et al. A changing picture of shigellosis in southern Vietnam: shifting species dominance, antimicrobial susceptibility and clinical presentation. BMC Infect Dis 2009;9(Pt 2):281-283. https://doi.org/10.1099/jmm.0.002949-0