Epidemiological and Clinical Characteristics of the Systemic Lupus Erythematosus at Vinh Phuc Obstetrics and Pediatrics Hospital

Vu Thi Huyen, Nguyen Van Nhien

Main Article Content

Abstract

Purpose: To describe the epidemiological and clinical characteristics of the systemic lupus erythematosus of patients coming to Vinh Phuc Obstetrics and Pediatrics Hospital in 2019.


Methods: A cross-sectional descriptive study was conducted on pediatric patients diagnosed with SLE according to Low Association standards of The United States 1982 (updated 1997) admitted and treated at Vinh Phuc Obstetrics and Pediatrics Hospital from 01/2018 to 12/2019.


Results: Percentage of female was 82.5%, 75.4% live in rural areas. Onset of symptoms 64.9% were fatigue, 57.9% were fever. Over 80% had damage to the skin, mucous membranes and blood. 84.2% had butterfly erythema, 64.9% sensitivity to light, 50.9% mouth ulcers, 42.1% arthritis, 50.9% anorexia, 91.2% hematuria, 87, 7% urinary protein, 61.4% edema, 50.9% kidney damage.


Conclusions: Systemic lupus erythematosus usually occurs in females, > 10 years old, the average onset age was 12.7. The disease causes the most damage in the skin, mucous membranes, hematology, musculoskeletal, and kidney. The most common and prominent non-renal lesions were: anemia, erythema papilloma, arthritis, pericardial effusion, pleural effusion. Common kidney damage was edema, microscopic hematuria, proteinuria, leukocytes.

Article Details

Keywords

SLE, children

References

[1] Tuan HM, Kim HT. Risk factors for hospital infections in the ICU. Medical and Pharmaceutical News 2005;6:139-142 (in Vietnamese)
[2] Tuan NM. Immune hemolysis in children. Residency Graduate Thesis in Paediatrics, University of Medicine and Pharmacy, Ho Chi Minh City 2002. (in Vietnamese)
[3] Cassidy JT. Systemic lupus erythematosus, Juvenile dermatomyositis, Scleroderma and Vasculitis. Kelly's textbook of Rheumatology, 6th ed. W.B Saunders; 2001, p. 1316-1318.
[4] Lehman Thomas JA, Janet A. Mouradian. Systemic lupus erythematosus, Pediatric nephrology, 4th ed, Lippincott Williams & Wilkins; 1999, p. 793-808.
[5] Bahabri S, Sabban E, Rashed A et al. Juvenile systemic lupus erythematosus in 60 Saudi children. Ann Saudi Med 2019;17(6):612-615. https://doi.org/10.514 4/0256-4947.1997.612
[6] Iqbal S, Sher MR, Good RA et al. Diversity in presenting manifestations of systemic lupus erythematosus in children. J Pediatr 1999;135(4):500-505. https://doi.org/10.10 16/s0022-3476(99)70174-5.
[7] Glidden RS, Mantzouranis EC, Borel Y. Systemic lupus erythematosus in childhood: clinical manifestations and improved survival in fifty-five patients. Clin Ummunol Immunopathol 1983;29(2):196-210. https://doi.org/10.101 6/0090-1229(83)90024-7
[8] Fortuna G, Brennan MT. Systemic lupus erythematosus: epidemiology, pathophy- siology, manifestations, and management. Dent Clin North Am 2013;57(4):631-55. https://doi.org/10.1016/j.cden.2013.06.003.
[9] Feng X, Zou Y, Pan W. Associations of
clinical features and prognosis with age at disease onset in patients with systemic lupus erythematosus. Lupus 2014;23(3): 327-340. https://doi.org/10.1177/096120331 3513508.
[10] Levy DM, Kamphuis. Systemic lupus erythematosus in children and adolescents. Pediatr Clin North Am 2012;59(2): 345-364. https://doi.org/10.1016/j.pcl.2012.03.0 07.