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Objectives: to determine the prevalance of Cushing’s syndrome and investigate plasma cortisol levels in children with SRNS. Subjects: 182 children with SRNS at Vietnam National Children’s Hospital from June 2018 to July 2019 were invoved in the study. Methods Descride and crossesional study. Results: The prevalence of Cushing syndrome in children with SRNS was 37.4%, mainly in man (78%) and the group of children from 2 to 10 years old. Duration of using corticoid below 5 years had the prevalance of Cushing syndrome was 27.2%. Low plasma cortisol levels in children with Cushing syndrome accounted for 60.3%, markedly low when children with changes in body shape as round face (100%), weight gain (91.2%), cetral fat (94.1%) and hirsutism (82.4%). Conclusion: children with SRNS had a high rate of Cushing’s syndrome, mainly in boys and ages from 2 to 10 years old. Plasma cortisol levels decreased clearly in 2 children with Cushing’s syndrome with changes in body shape or round face, weight gain, central fat, hirsutism.
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